Biological screening of rain forest plot trees from Palawan Island (Philippines)
Identifieur interne : 002284 ( Main/Exploration ); précédent : 002283; suivant : 002285Biological screening of rain forest plot trees from Palawan Island (Philippines)
Auteurs : F. D. Horgen [États-Unis] ; R. A. Edrada [Philippines] ; G. De Los Reyes [Philippines] ; F. Agcaoili [Philippines] ; D. A. Madulid [Philippines] ; V. Wongpanich [États-Unis] ; C. K. Angerhofer [États-Unis] ; J. M. Pezzuto [États-Unis] ; D. D. Soejarto [États-Unis] ; N. R. Farnsworth [États-Unis]Source :
- Phytomedicine [ 0944-7113 ] ; 2001.
English descriptors
- Teeft :
- Acronychia, Acronychia laurifolia, Aglaia, Alkaloid, Alphonsea, Antiplasmodial, Antiplasmodial activity, Ardisia, Ardisia iwahigensis, Argyratus, Artemia, Artemia salina, Assay, Bark sample, Bark samples, Bioassay, Biological screening, Blume, Brine, Brine shrimp, Brine shrimp assay, Brine shrimp toxicity, Cancer cell lines, Cancer cells, Cauliflorum, Cell line, Cinnamomum griffithii, Clone, Croton, Cytotoxic, Cytotoxicity, Cytotoxicity assays, David horgen, Distinct samples, Dmso, Dysoxylum, Dysoxylum cauliflorum, Euphorbiaceae, Extract, Falciparum, Farnsworth, Foxworthyi, Horgen, Iwahigensis, Laurifolia, Leaf twig, Leiophyllus, Lithocarpus, Lncap, Meliaceae, Merr, Methanol extracts, Negative controls, Nonlinear regression analysis, Other cell lines, Palawan, Palawan island, Percent inhibition, Pezzuto, Phytochemistry, Plant part, Plasmodium, Plasmodium falciparum, Previous chemical reports, Rain forest plot trees, Salina, Second root sample, Selectivity, Shrimp, Soejarto, Swintonia, Swintonia foxworthyi, Syzygium, Toxicity, Tree species, Twig, Vinblastine, Voucher, Xanthophyllum, Xanthophyllum flavescens.
Abstract
Summary Study plots totaling 0.2 Ha were established in primary forest in the highlands of central Palawan Island, Philippines. Samples of various anatomical parts [typically leaf twig (lftw), stem bark (sb), and root (rt)] were collected from all tree species represented within the plots by individuals having a diameter at breast height 10 cm. In all, 211 distinct samples were obtained from 68 tree species, representing 35 families (not including samples from 4 indeterminate species). Methanol extracts of these samples were tested in in vitro antiplasmodial, brine shrimp toxicity, and cytotoxicity assays. The following samples showed an IC50 10 gmL against either chloroquine-sensitive or chloroquine-resistant clones of Plasmodium falciparum: Acronychia laurifolia (sb), Agathis celebica (lftw), Aglaia sp. 1 (sb), Aglaia sp. 2 (lftw, rt), Bhesa sp. 1 (rt), Cinnamomum griffithii (lftw), Croton leiophyllus (rt), Dysoxylum cauliflorum (rt), Garcinia macgregorii (sb), Lithocarpus sp. 1 (rt, sb), Meliosma pinnata ssp. macrophylla (lftw, rt), Myristica guatteriifolia (lftw), Ochrosia glomerata (rt, sb), Swintonia foxworthyi (lftw), Syzygium sp. 1 (rt), Turpinia pomifera (rt), and Xanthophyllum flavescens (sb). Secondly, those samples which displayed 50 immobilization of brine shrimp at 100 gmL were: Acronychia laurifolia (lftwfruit, rt, sb), Agathis celebica (lftw, sb), Aglaia sp. 1 (lftw), Alphonsea sp. 1 (rt), Ardisia iwahigensis (lftw), Arthrophyllum ahernianum (lftw, rt, sb), Castanopsis cf. evansii (rt), Cinnamomum griffithii (lftw, rt), Croton argyratus (lftw), C. leiophyllus (lftw, rt), Dysoxylum cauliflorum (fruit, lftw, rt), Euonymus javanicus (rt), Glochidion sp. 1 (rt), Polyosma sp. 1 (rt), Symplocos polyandra (rt), Timonius gammillii (sb), and Xanthophyllum flavescens (rt). Lastly, samples which exhibited an IC50 20 gmL against one or more of the cancer cell lines employed (LU1, KB, KB-V1, P-388, LNCaP, or ZR-751) include: Acronychia laurifolia (lftwfruit, rt, sb), Aglaia sp. 1 (sb), Aglaia sp. 2 (rt), Alphonsea sp. 1 (rt), Ardisia iwahigensis (lftw, rt, sb), Astronia cumingiana (sb), Croton argyratus (lftw, rt, sb), C. leiophyllus (lftw, rt), Dimorphocalyx murina (lftw, rt, sb), Lithocarpus caudatifolius (rt, sb), Litsea cf. sibuyanensis (rt), Syzygium cf. attenuatum (rt, sb), S. confertum (sb), Ternstroemia gitingensis (rt), and Ternstroemia sp. 1 (rt, sb).
Url:
DOI: 10.1078/0944-7113-00019
Affiliations:
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D." last="Horgen">F. D. Horgen</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago</wicri:regionArea><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName><orgName type="university">Université de l'Illinois à Chicago</orgName></affiliation></author><author><name sortKey="Edrada, R A" sort="Edrada, R A" uniqKey="Edrada R" first="R. A." last="Edrada">R. A. Edrada</name><affiliation wicri:level="1"><country xml:lang="fr">Philippines</country><wicri:regionArea>College of Pharmacy, University of the Philippines Manila, Manila</wicri:regionArea><wicri:noRegion>Manila</wicri:noRegion></affiliation></author><author><name sortKey="De Los Reyes, G" sort="De Los Reyes, G" uniqKey="De Los Reyes G" first="G." last="De Los Reyes">G. De Los Reyes</name><affiliation wicri:level="1"><country xml:lang="fr">Philippines</country><wicri:regionArea>College of Pharmacy, University of the Philippines Manila, Manila</wicri:regionArea><wicri:noRegion>Manila</wicri:noRegion></affiliation></author><author><name sortKey="Agcaoili, F" sort="Agcaoili, F" uniqKey="Agcaoili F" first="F." last="Agcaoili">F. Agcaoili</name><affiliation wicri:level="1"><country xml:lang="fr">Philippines</country><wicri:regionArea>College of Pharmacy, University of the Philippines Manila, Manila</wicri:regionArea><wicri:noRegion>Manila</wicri:noRegion></affiliation></author><author><name sortKey="Madulid, D A" sort="Madulid, D A" uniqKey="Madulid D" first="D. A." last="Madulid">D. A. Madulid</name><affiliation wicri:level="1"><country xml:lang="fr">Philippines</country><wicri:regionArea>Philippine National Museum, Manila</wicri:regionArea><wicri:noRegion>Manila</wicri:noRegion></affiliation></author><author><name sortKey="Wongpanich, V" sort="Wongpanich, V" uniqKey="Wongpanich V" first="V." last="Wongpanich">V. Wongpanich</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago</wicri:regionArea><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName><orgName type="university">Université de l'Illinois à Chicago</orgName></affiliation></author><author><name sortKey="Angerhofer, C K" sort="Angerhofer, C K" uniqKey="Angerhofer C" first="C. K." last="Angerhofer">C. K. Angerhofer</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago</wicri:regionArea><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName><orgName type="university">Université de l'Illinois à Chicago</orgName></affiliation></author><author><name sortKey="Pezzuto, J M" sort="Pezzuto, J M" uniqKey="Pezzuto J" first="J. M." last="Pezzuto">J. M. Pezzuto</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago</wicri:regionArea><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName><orgName type="university">Université de l'Illinois à Chicago</orgName></affiliation></author><author><name sortKey="Soejarto, D D" sort="Soejarto, D D" uniqKey="Soejarto D" first="D. D." last="Soejarto">D. D. Soejarto</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago</wicri:regionArea><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName><orgName type="university">Université de l'Illinois à Chicago</orgName></affiliation></author><author><name sortKey="Farnsworth, N R" sort="Farnsworth, N R" uniqKey="Farnsworth N" first="N. R." last="Farnsworth">N. R. Farnsworth</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago</wicri:regionArea><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName><orgName type="university">Université de l'Illinois à Chicago</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Phytomedicine</title><title level="j" type="abbrev">PHYMED</title><idno type="ISSN">0944-7113</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">8</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="71">71</biblScope><biblScope unit="page" to="81">81</biblScope></imprint><idno type="ISSN">0944-7113</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0944-7113</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acronychia</term><term>Acronychia laurifolia</term><term>Aglaia</term><term>Alkaloid</term><term>Alphonsea</term><term>Antiplasmodial</term><term>Antiplasmodial activity</term><term>Ardisia</term><term>Ardisia iwahigensis</term><term>Argyratus</term><term>Artemia</term><term>Artemia salina</term><term>Assay</term><term>Bark sample</term><term>Bark samples</term><term>Bioassay</term><term>Biological screening</term><term>Blume</term><term>Brine</term><term>Brine shrimp</term><term>Brine shrimp assay</term><term>Brine shrimp toxicity</term><term>Cancer cell lines</term><term>Cancer cells</term><term>Cauliflorum</term><term>Cell line</term><term>Cinnamomum griffithii</term><term>Clone</term><term>Croton</term><term>Cytotoxic</term><term>Cytotoxicity</term><term>Cytotoxicity assays</term><term>David horgen</term><term>Distinct samples</term><term>Dmso</term><term>Dysoxylum</term><term>Dysoxylum cauliflorum</term><term>Euphorbiaceae</term><term>Extract</term><term>Falciparum</term><term>Farnsworth</term><term>Foxworthyi</term><term>Horgen</term><term>Iwahigensis</term><term>Laurifolia</term><term>Leaf twig</term><term>Leiophyllus</term><term>Lithocarpus</term><term>Lncap</term><term>Meliaceae</term><term>Merr</term><term>Methanol extracts</term><term>Negative controls</term><term>Nonlinear regression analysis</term><term>Other cell lines</term><term>Palawan</term><term>Palawan island</term><term>Percent inhibition</term><term>Pezzuto</term><term>Phytochemistry</term><term>Plant part</term><term>Plasmodium</term><term>Plasmodium falciparum</term><term>Previous chemical reports</term><term>Rain forest plot trees</term><term>Salina</term><term>Second root sample</term><term>Selectivity</term><term>Shrimp</term><term>Soejarto</term><term>Swintonia</term><term>Swintonia foxworthyi</term><term>Syzygium</term><term>Toxicity</term><term>Tree species</term><term>Twig</term><term>Vinblastine</term><term>Voucher</term><term>Xanthophyllum</term><term>Xanthophyllum flavescens</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Summary Study plots totaling 0.2 Ha were established in primary forest in the highlands of central Palawan Island, Philippines. Samples of various anatomical parts [typically leaf twig (lftw), stem bark (sb), and root (rt)] were collected from all tree species represented within the plots by individuals having a diameter at breast height 10 cm. In all, 211 distinct samples were obtained from 68 tree species, representing 35 families (not including samples from 4 indeterminate species). Methanol extracts of these samples were tested in in vitro antiplasmodial, brine shrimp toxicity, and cytotoxicity assays. The following samples showed an IC50 10 gmL against either chloroquine-sensitive or chloroquine-resistant clones of Plasmodium falciparum: Acronychia laurifolia (sb), Agathis celebica (lftw), Aglaia sp. 1 (sb), Aglaia sp. 2 (lftw, rt), Bhesa sp. 1 (rt), Cinnamomum griffithii (lftw), Croton leiophyllus (rt), Dysoxylum cauliflorum (rt), Garcinia macgregorii (sb), Lithocarpus sp. 1 (rt, sb), Meliosma pinnata ssp. macrophylla (lftw, rt), Myristica guatteriifolia (lftw), Ochrosia glomerata (rt, sb), Swintonia foxworthyi (lftw), Syzygium sp. 1 (rt), Turpinia pomifera (rt), and Xanthophyllum flavescens (sb). Secondly, those samples which displayed 50 immobilization of brine shrimp at 100 gmL were: Acronychia laurifolia (lftwfruit, rt, sb), Agathis celebica (lftw, sb), Aglaia sp. 1 (lftw), Alphonsea sp. 1 (rt), Ardisia iwahigensis (lftw), Arthrophyllum ahernianum (lftw, rt, sb), Castanopsis cf. evansii (rt), Cinnamomum griffithii (lftw, rt), Croton argyratus (lftw), C. leiophyllus (lftw, rt), Dysoxylum cauliflorum (fruit, lftw, rt), Euonymus javanicus (rt), Glochidion sp. 1 (rt), Polyosma sp. 1 (rt), Symplocos polyandra (rt), Timonius gammillii (sb), and Xanthophyllum flavescens (rt). Lastly, samples which exhibited an IC50 20 gmL against one or more of the cancer cell lines employed (LU1, KB, KB-V1, P-388, LNCaP, or ZR-751) include: Acronychia laurifolia (lftwfruit, rt, sb), Aglaia sp. 1 (sb), Aglaia sp. 2 (rt), Alphonsea sp. 1 (rt), Ardisia iwahigensis (lftw, rt, sb), Astronia cumingiana (sb), Croton argyratus (lftw, rt, sb), C. leiophyllus (lftw, rt), Dimorphocalyx murina (lftw, rt, sb), Lithocarpus caudatifolius (rt, sb), Litsea cf. sibuyanensis (rt), Syzygium cf. attenuatum (rt, sb), S. confertum (sb), Ternstroemia gitingensis (rt), and Ternstroemia sp. 1 (rt, sb).</div></front></TEI><affiliations><list><country><li>Philippines</li><li>États-Unis</li></country><region><li>Illinois</li></region><settlement><li>Chicago</li></settlement><orgName><li>Université de l'Illinois à Chicago</li></orgName></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Horgen, F D" sort="Horgen, F D" uniqKey="Horgen F" first="F. D." last="Horgen">F. D. Horgen</name></region><name sortKey="Angerhofer, C K" sort="Angerhofer, C K" uniqKey="Angerhofer C" first="C. K." last="Angerhofer">C. K. Angerhofer</name><name sortKey="Farnsworth, N R" sort="Farnsworth, N R" uniqKey="Farnsworth N" first="N. R." last="Farnsworth">N. R. Farnsworth</name><name sortKey="Pezzuto, J M" sort="Pezzuto, J M" uniqKey="Pezzuto J" first="J. M." last="Pezzuto">J. M. Pezzuto</name><name sortKey="Soejarto, D D" sort="Soejarto, D D" uniqKey="Soejarto D" first="D. D." last="Soejarto">D. D. Soejarto</name><name sortKey="Wongpanich, V" sort="Wongpanich, V" uniqKey="Wongpanich V" first="V." last="Wongpanich">V. Wongpanich</name></country><country name="Philippines"><noRegion><name sortKey="Edrada, R A" sort="Edrada, R A" uniqKey="Edrada R" first="R. A." last="Edrada">R. A. Edrada</name></noRegion><name sortKey="Agcaoili, F" sort="Agcaoili, F" uniqKey="Agcaoili F" first="F." last="Agcaoili">F. Agcaoili</name><name sortKey="De Los Reyes, G" sort="De Los Reyes, G" uniqKey="De Los Reyes G" first="G." last="De Los Reyes">G. De Los Reyes</name><name sortKey="Madulid, D A" sort="Madulid, D A" uniqKey="Madulid D" first="D. A." last="Madulid">D. A. Madulid</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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